Get ready for fireworks at Anfield – the ultimate Premier League rivalry is heating up with Liverpool taking on Manchester United! This clash isn't just about bragging rights; it's a battle that could shape the season's narrative. But here's where it gets intriguing: with injuries and tactical tweaks in play, who will Slot unleash to deliver the knockout blow? Let's dive into the latest team news, predicted lineups, and injury updates, breaking it down step by step so even newcomers to the game can follow along.
First off, Liverpool fans can breathe a sigh of relief – Ryan Gravenberch looks set to be available for this massive showdown against Manchester United. That’s a boost for manager Arne Slot, as the Dutch midfielder's presence could provide crucial energy and creativity in the midfield. Additionally, defender Ibrahima Konate is expected to feature, bringing his solid presence and aerial ability to help anchor the backline. For beginners, think of Konate as the rock at the heart of defense, someone who wins headers and blocks shots to keep the opposition at bay.
However, there's a significant setback: goalkeeper Alisson Becker will be sidelined for at least this weekend and the next, according to Slot himself. The Brazilian star is still recovering from a hamstring injury, which means he won't be involved in training just yet. As a result, Liverpool's top-choice shot-stopper for the goal will miss not only this Sunday's game against United but also the midweek Champions League trip to Eintracht Frankfurt and likely next Saturday's match at Brentford. This extends Alisson's absence, giving substitute Giorgi Mamardashvili – the Georgian goalkeeper who impressed fans with his Premier League debut before the international break – more opportunities to shine and prove himself under pressure.
Shifting to the defensive lineup, Milos Kerkez might hold onto his spot at left-back, especially after some recent fatigue from veteran Andy Robertson. But the real puzzle for Slot is the right side. New summer signing Jeremie Frimpong, who arrived for a hefty fee, has only managed one Premier League start so far. Instead, Conor Bradley and even Dominik Szoboszlai have been favored there. Szoboszlai, typically a midfielder, has been versatile in defense – a tactic some managers use to add creativity or cover for injuries. And this is the part most people miss: Slot could give Frimpong a fresh start after his restful international break, potentially shifting Szoboszlai back into midfield to partner with Gravenberch. Imagine that dynamic duo controlling the game's tempo, linking defense to attack seamlessly.
Up front, the attacking midfield trio could feature Florian Wirtz in the central role, making it tough for Alexis Mac Allister to squeeze in. Mac Allister, a key figure known for his passing and vision, might watch from the sidelines this time. On the right wing, though, Mohamed Salah is a guaranteed starter. Despite a sluggish start to the season – where his usual flair and goal-scoring prowess haven't fully materialized – Salah bounced back by netting two goals for Egypt during the international break. And here's a fun fact to remember: no player in Premier League history has more goal involvements against United than Salah, with 13 goals and six assists from 15 appearances. That's record-breaking territory for the Egyptian wizard!
Meanwhile, Cody Gakpo, who contributed to four goals for the Netherlands recently, might feel overlooked if he's benched, especially after scoring Liverpool's only goal in the last outing against Chelsea. This setup gives Slot a chance to experiment with the frontline, possibly including both Hugo Ekitike and Alexander Isak. Ekitike could slide into the left-wing role, replacing Gakpo, while Isak leads the attack. But if Ekitike starts up front, pushing Isak out of the starting XI, Gakpo should retain his place. For context, these experiments help Slot find the perfect chemistry – like mixing ingredients in a recipe until it tastes just right – to build a squad that can challenge for trophies.
But here's where it gets controversial: Is Slot risking team cohesion by rotating so heavily, or could this bold approach unlock untapped potential? Critics might argue that benching experienced players like Gakpo could disrupt morale, while supporters point to the excitement of fresh faces like Frimpong or Ekitike shaking things up. What do you think – is this experimentation smart strategy, or a recipe for inconsistency?
Based on all this, here's our predicted Liverpool XI in a 4-2-3-1 formation: Mamardashvili in goal; Frimpong, Konate, Van Dijk, and Kerkez in defense; Szoboszlai and Gravenberch in midfield; Salah, Wirtz, and Ekitike across the attack; with Isak up top.
Injured players to note: Alisson, as mentioned, plus Ben Chrisene (likely a typo for Leoni or similar, but assuming based on context) and Wataru Endo.
Kickoff is at 4:30pm BST on Sunday, October 19, 2025, at the iconic Anfield stadium.
Catch all the action on Sky Sports Main Event – don't miss a minute of this electric encounter!
What are your predictions for the match? Do you agree with our lineup choices, or do you think Slot should stick to the tried-and-true? Share your thoughts in the comments – let's debate!
